To send your first SMS with Twilio and Python you'll just need the Twilio-Python helper library to get started.
# Download the twilio-python library from http://twilio.com/docs/libraries
from twilio.rest import TwilioRestClient
# Find these values at https://twilio.com/user/account
account_sid = "ACXXXXXXXXXXXXXXXXX"
auth_token = "YYYYYYYYYYYYYYYYYY"
client = TwilioRestClient(account_sid, auth_token)
message = client.messages.create(to="+12316851234", from_="TWILIO_NUMBER",
body="Hello there, StackOverflow!")