You need to keep track of some threads metrics to watch your Varnish Cache. Is it running out of OS resources or is it functioning well.
varnishstat -1 | grep "threads\|thread_queue_len\|sess_queued" MAIN.threads 100 . Total number of threads MAIN.threads_limited 1 0.00 Threads hit max MAIN.threads_created 3715 0.00 Threads created MAIN.threads_destroyed 3615 0.00 Threads destroyed MAIN.threads_failed 0 0.00 Thread creation failed MAIN.thread_queue_len 0 . Length of session queue MAIN.sess_queued 2505 0.00 Sessions queued for thread
thread_queue_len isn't 0 it means that Varnish is out of resources and have started to queue requests. This will decrease performance of those requests. You need to investigate why.
Watch also out for
threads_failed. If this increases it means your server is out of resources somehow. Increasing numbers in
threads_limited means you might need to increase your servers