When you do a groupby you can select either a single column or a list of columns:
In [11]: df = pd.DataFrame([[1, 1, 2], [1, 2, 3], [2, 3, 4]], columns=["A", "B", "C"])
In [12]: df
Out[12]:
   A  B  C
0  1  1  2
1  1  2  3
2  2  3  4
In [13]: g = df.groupby(...