Given a DataFrame with MultiIndex columns
# build an example DataFrame
midx = pd.MultiIndex(levels=[['zero', 'one'], ['x','y']], labels=[[1,1,0,],[1,0,1,]])
df = pd.DataFrame(np.random.randn(2,3), columns=midx)
In [2]: df
Out[2]:
one zero
y x y
0 0.785806 -0.679039 0.513451
1 -0.337862 -0.350690 -1.423253
If you want to change the columns to standard columns (not MultiIndex), just rename the columns.
df.columns = ['A','B','C']
In [3]: df
Out[3]:
A B C
0 0.785806 -0.679039 0.513451
1 -0.337862 -0.350690 -1.423253