Creating a separate instance of the WP_Query
object is easy:
$query_args = array(
'post_type' => 'post',
'post_per_page' => 10
);
$my_query = new WP_Query($query_args);
if( $my_query->have_posts() ):
while( $my_query->have_posts() ): $my_query->the_post();
//My custom query loop
endwhile;
endif;
wp_reset_postdata();
Notice that you need to build the query arguments array to your specification. For more details, look at WP_Query codex page.